In the medical libraries, newer technologies are being increasingly used to collect, store, retrieve and disseminate a huge amount of information to the medical professionals in their day-to-day education, research and clinical practices. The medical websites and databases developed by medical institutions, associations, agencies and publishers are available on the internet to provide the latest information. In a developing country like India, medical professionals are quite aware of the new technologies used by their counterparts in the developed nations. In the institutes of national importance such as the Post Graduate Institute of Medical Education and Research, Chandigarh (PGIMER) and the All India Institute of Medical Sciences, New Delhi (AIIMS), the facilities like computerization, internet, medical databases, e-journals and e-books are readily available for the users. However, due to inadequate infrastructure and lack of funds, the above services are only partially available in other medical instituti ons in India. The present paper describes the developments and current challenges in the application of new technologies in the libraries of PGIMER and AIIMS in the global context.